CYP3A4 is involved in the metabolism of the anticonvulsant gabapentin, which is used to treat neuropathic pain and epilepsy. It may be oxidised using this enzyme to produce gabapentinol or norgabapentinol.It was first authorised as Neurontin in 1993 and reapproved as Gabapentin in 2005. It is used to relieve pain in the nerves, such as that caused by shingles and diabetic neuropathy. Lennox-Gastaut syndrome, some forms of postherpetic neuralgia, and Bell's palsy are other conditions for which it is used to help control seizures in children who are at least 2 years old.
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