Initial Validation: Clean Room Validation should be performed during the initial installation and commissioning of the cleanroom. This involves a thorough assessment of the design, construction, and performance of the cleanroom to ensure it meets the required standards and Clean Room Validation specifications. Periodic Revalidation: After the initial validation, periodic revalidation should be conducted at regular intervals. The frequency of revalidation is typically specified in regulatory guidelines or industry standards. Common intervals are annually, biannually, or every two to three years. The specific time frame may vary depending on the criticality of the cleanroom operations and the risk of contamination.

Significant Changes: Whenever there are significant changes to the cleanroom, its equipment, or processes, revalidation should be performed. This ensures that any modifications or alterations do not adversely affect the cleanroom's performance or contaminate the controlled environment. After Maintenance or Repairs: If major maintenance or repairs are performed on the cleanroom or its critical components, revalidation should be conducted to verify that the cleanroom's integrity and performance have not been compromised.

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